Quick answer
Italy users should check EUR deposits, SEPA withdrawal options, supported cards, KYC tiers, tax documentation and exchange product availability.
What to compare
Check KYC requirements, supported fiat rails, card fees, withdrawal costs, country restrictions, custody model and whether the exchange supports the exact products you need.
Safer workflow
Start with a small deposit, test a withdrawal, enable two-factor authentication and move long-term holdings to self-custody when active exchange access is not needed.